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Heart Failure

Clinical Indications and Science Learning Series

Clinical Trials & Science

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Heart Failure >
Clinical Trials & Science

Episodes

Impact Of Rapid Up-Titration of Guideline-Directed Medical Therapies On Quality of Life: Insights From The STRONG-HF Trial

Impact Of Rapid Up-Titration of Guideline-Directed Medical Therapies On Quality of Life: Insights From The STRONG-HF Trial

9 min.

Introduction Of Guideline Directed Medical Therapy And Native Heart Recovery In Patients Supported By Impella 5.5

Introduction Of Guideline Directed Medical Therapy And Native Heart Recovery In Patients Supported By Impella 5.5

9 min.

Multicenter Development and Validation of a Supervised Machine Learning Risk Model to Predict Right Ventricular Failure Following Mechanical Circulatory Support: The STOP-RVF Score

Multicenter Development and Validation of a Supervised Machine Learning Risk Model to Predict Right Ventricular Failure Following Mechanical Circulatory Support: The STOP-RVF Score

12 min.

AI Assisted Identification of Super responders for Ultrafiltration can Reduce 90-Day Readmission Rates: Evidence from AVOID-HF Trial

AI Assisted Identification of Super responders for Ultrafiltration can Reduce 90-Day Readmission Rates: Evidence from AVOID-HF Trial

9 min.

Aquapheresis for Management of Decompensated Heart Failure: A Re-appraisal of AVOID-HF

Aquapheresis for Management of Decompensated Heart Failure: A Re-appraisal of AVOID-HF

10 min.

Serial Direct Sodium Removal in Patients with Heart Failure and Diuretic Resistance

Serial Direct Sodium Removal in Patients with Heart Failure and Diuretic Resistance

12 min.

A Novel Cardiac Scale and Algorithm for Detecting Worsening Congestion Preceding Heart Failure Events (HFEs): A Preliminary Analysis of the SCALE-HF 1 Study

A Novel Cardiac Scale and Algorithm for Detecting Worsening Congestion Preceding Heart Failure Events (HFEs): A Preliminary Analysis of the SCALE-HF 1 Study

10 min.

Cardiac Contractility Modulator as an Option for Advanced Heart Failure Patients Dependent on Low Dose inotropes

Cardiac Contractility Modulator as an Option for Advanced Heart Failure Patients Dependent on Low Dose inotropes

8 min.

Impact of Noninvasive, Low-Intensity Ultrasound Energy Delivery to the Kidney on Urine Output in Acutely Decompensated Heart Failure Patients

Impact of Noninvasive, Low-Intensity Ultrasound Energy Delivery to the Kidney on Urine Output in Acutely Decompensated Heart Failure Patients

10 min.

Acute and Chronic Outcomes in Early Feasibility Evaluation of Device-Based Thoracic Duct Decompression in Hospitalized Acute Decompensated Heart Failure Patients

Acute and Chronic Outcomes in Early Feasibility Evaluation of Device-Based Thoracic Duct Decompression in Hospitalized Acute Decompensated Heart Failure Patients

13 min.

Transcatheter pulmonary artery banding [PAB] for HFrEF: Initial results of invasive exercise hemodynamics and updates from the ongoing First-in-Human trial.

Transcatheter pulmonary artery banding [PAB] for HFrEF: Initial results of invasive exercise hemodynamics and updates from the ongoing First-in-Human trial.

10 min.

Initial Results from the First-in-Human Study of the Supira System

Initial Results from the First-in-Human Study of the Supira System

9 min.

Preliminary Results from the Early Feasibility Study of the FIRE1 System in Heart Failure Patients

Preliminary Results from the Early Feasibility Study of the FIRE1 System in Heart Failure Patients

9 min.

RECOVER-HF Pilot Study: Synchronized Diaphragmatic Stimulation for HFrEF Therapy

RECOVER-HF Pilot Study: Synchronized Diaphragmatic Stimulation for HFrEF Therapy

10 min.

Relationship of Patient Adherence to the Performance of a Remote Speech Analysis System to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients

Relationship of Patient Adherence to the Performance of a Remote Speech Analysis System to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients

13 min.

A Nationwide Study of a Remote Patient Monitoring and Intervention Program: The Impact on Heart Failure Clinical Outcomes and Healthcare Cost

A Nationwide Study of a Remote Patient Monitoring and Intervention Program: The Impact on Heart Failure Clinical Outcomes and Healthcare Cost

13 min.

Short-term Atrial Shunt Device-Induced Changes in Cardiac  Structure/Function and Risk of Subsequent Heart Failure Events: Findings from the REDUCE-LAP HF II Randomized Clinical Trial

Short-term Atrial Shunt Device-Induced Changes in Cardiac Structure/Function and Risk of Subsequent Heart Failure Events: Findings from the REDUCE-LAP HF II Randomized Clinical Trial

8 min.

Derivation and Validation of a Multicenter Model to Identify Candidates for Advanced HF Therapies with High Potential to Achieve post-LVAD Reverse Cardiac Remodeling

Derivation and Validation of a Multicenter Model to Identify Candidates for Advanced HF Therapies with High Potential to Achieve post-LVAD Reverse Cardiac Remodeling

12 min.

Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: One Year Results of the REBALANCE-HF Roll-in Cohort

Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: One Year Results of the REBALANCE-HF Roll-in Cohort

7 min.

Transcatheter Pulmonary Artery Banding In Chronic Heart Failure [HFrEF]: Results From the First-in-Human Study

Transcatheter Pulmonary Artery Banding In Chronic Heart Failure [HFrEF]: Results From the First-in-Human Study

8 min.

Wearable HF Monitoring Devices: Landscape Overview, Patient Indications, and Implementation Science

Wearable HF Monitoring Devices: Landscape Overview, Patient Indications, and Implementation Science

25 min.

The Conundrum of Clinical Trials in Cardiogenic Shock

The Conundrum of Clinical Trials in Cardiogenic Shock

16 min.

Acute Decompensated HF Trials: Who Should be Enrolled and What Should the Study Endpoints Be?

Acute Decompensated HF Trials: Who Should be Enrolled and What Should the Study Endpoints Be?

15 min.

Long-term Outcomes of Endovascular Baroreflex Amplification in Symptomatic Patients With HFrEF

Long-term Outcomes of Endovascular Baroreflex Amplification in Symptomatic Patients With HFrEF

11 min.

Transcatheter Pulmonary Artery Banding in Chronic Heart Failure: Results From an Early Feasibility Study

Transcatheter Pulmonary Artery Banding in Chronic Heart Failure: Results From an Early Feasibility Study

11 min.

Current Clinical Evidence Following TR Interventions

Current Clinical Evidence Following TR Interventions

20 min.

The PRELIEVE Trial: Responder Analysis in the HFpEF Subgroup Regarding Baseline PVR, Pacemaker and Pressure Gradients

The PRELIEVE Trial: Responder Analysis in the HFpEF Subgroup Regarding Baseline PVR, Pacemaker and Pressure Gradients

11 min.

No-Implant Interatrial Shunt for Heart Failure With Preserved and Mildly Reduced Ejection Fraction: Six-Month Outcomes From Multi-Center Pilot Feasibility Studies

No-Implant Interatrial Shunt for Heart Failure With Preserved and Mildly Reduced Ejection Fraction: Six-Month Outcomes From Multi-Center Pilot Feasibility Studies

12 min.

Pulmonary Artery Denervation: Innovative Pulmonary Hypertension Therapies

Pulmonary Artery Denervation: Innovative Pulmonary Hypertension Therapies

9 min.

Next Trials in LVAD Therapy

Next Trials in LVAD Therapy

8 min.

Baroreflex Activation Therapy (BAT) in Patients With Heart Failure and a Reduced Ejection Fraction (BeAT-HF): Long-Term Outcomes

Baroreflex Activation Therapy (BAT) in Patients With Heart Failure and a Reduced Ejection Fraction (BeAT-HF): Long-Term Outcomes

9 min.

Splanchnic Nerve Denervation for HFrEF and HFpEF

Splanchnic Nerve Denervation for HFrEF and HFpEF

8 min.

Cardiac Contractility Modulation for HFrEF and HFpEF:  Impulse Dynamics

Cardiac Contractility Modulation for HFrEF and HFpEF: Impulse Dynamics

9 min.

Mechanical Stimulation of the Carotid Sinus: MobiusHD

Mechanical Stimulation of the Carotid Sinus: MobiusHD

5 min.

Aortic Arch Simulation (Enopace)

Aortic Arch Simulation (Enopace)

8 min.

Vagal Nerve Stimulation (ANTHEM)

Vagal Nerve Stimulation (ANTHEM)

8 min.

Blood Volume Analysis Guided Heart Failure Management: A Pilot Randomized Controlled Trial

Blood Volume Analysis Guided Heart Failure Management: A Pilot Randomized Controlled Trial

9 min.

Exercise Capacity and Health-Related Quality of Life With Furoscix:  Data From the AT HOME Pilot Study

Exercise Capacity and Health-Related Quality of Life With Furoscix:  Data From the AT HOME Pilot Study

8 min.

Longer Term Effects of Hemodynamic Monitoring on Outcomes: A Combined Data Analysis of Patients with HFrEF in CHAMPION, GUIDE-HF, and LAPTOP-HF

Longer Term Effects of Hemodynamic Monitoring on Outcomes: A Combined Data Analysis of Patients with HFrEF in CHAMPION, GUIDE-HF, and LAPTOP-HF

11 min.

Impact of the V-Wave® Ventura® Interatrial Shunt Device on Right and Left Ventricular Structure and Function: Complete 12-Month Results of the RELIEVE-HF Roll-in Cohort

Impact of the V-Wave® Ventura® Interatrial Shunt Device on Right and Left Ventricular Structure and Function: Complete 12-Month Results of the RELIEVE-HF Roll-in Cohort

10 min.

Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial

Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial

10 min.

Influence of Body Surface Area, and Ventricular Dimensions on Impella 5.5 Outcomes

Influence of Body Surface Area, and Ventricular Dimensions on Impella 5.5 Outcomes

9 min.

Heart Failure Journal Editors' Forum: JACC: Basic to Translational Science

Heart Failure Journal Editors' Forum: JACC: Basic to Translational Science

7 min.

Heart Failure Journal Editors' Forum - Circ: Heart Failure

Heart Failure Journal Editors' Forum - Circ: Heart Failure

6 min.

Heart Failure Journal Editors' Forum: JACC - Heart Failure

Heart Failure Journal Editors' Forum: JACC - Heart Failure

7 min.

Heart Failure Journal Editors' Forum - JACC: Clinical Electrophysiology

Heart Failure Journal Editors' Forum - JACC: Clinical Electrophysiology

7 min.

Heart Failure Journal Editors' Forum: Structural Heart

Heart Failure Journal Editors' Forum: Structural Heart

7 min.

Pulmonary Artery Catheter Use in Patients with Heart Failure Cardiogenic Shock (HF-CS): An Analysis from the Cardiogenic Shock Working Group (CSWG)

Pulmonary Artery Catheter Use in Patients with Heart Failure Cardiogenic Shock (HF-CS): An Analysis from the Cardiogenic Shock Working Group (CSWG)

9 min.

Influence of Serum Potassium on the Decongestive Potential of Spironolactone: Insights from the ATHENA-HF Trial

Influence of Serum Potassium on the Decongestive Potential of Spironolactone: Insights from the ATHENA-HF Trial

9 min.

Clinical Profiling in Patients With HFpEF Phenotype Exhibiting Elevated Resting Supine and Normal Exercise Upright Pulmonary Capillary Wedge Pressures

Clinical Profiling in Patients With HFpEF Phenotype Exhibiting Elevated Resting Supine and Normal Exercise Upright Pulmonary Capillary Wedge Pressures

11 min.

Use of Remote Speech Analysis to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients

Use of Remote Speech Analysis to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients

11 min.

Physician-Directed Patient Self-Management in Heart Failure Using LA Pressure: Initial Insights From VECTOR-HF I & IIa Studies

Physician-Directed Patient Self-Management in Heart Failure Using LA Pressure: Initial Insights From VECTOR-HF I & IIa Studies

11 min.

Heart Failure Journal Editors' Forum: JCF

Heart Failure Journal Editors' Forum: JCF

7 min.

Heart Failure Journal Editors' Forum: Journal of Heart and Lung Transplant

Heart Failure Journal Editors' Forum: Journal of Heart and Lung Transplant

8 min.

Pros and Cons of the Win Ratio as the Primary Endpoint for Pivotal Heart Failure Trial

Pros and Cons of the Win Ratio as the Primary Endpoint for Pivotal Heart Failure Trial

10 min.

Strengths and Limitations of a Two-Phase (6-Month Intermediate Endpoints & 12-18 Month Mortality and Heart Failure Hospitalization) Design for Trials on Chronic Heart Failure Devices

Strengths and Limitations of a Two-Phase (6-Month Intermediate Endpoints & 12-18 Month Mortality and Heart Failure Hospitalization) Design for Trials on Chronic Heart Failure Devices

10 min.

Regulatory Aspects for Chronic Heart Failure Devices - FDA Perspective

Regulatory Aspects for Chronic Heart Failure Devices - FDA Perspective

10 min.

Clinically Meaningful and Practical Pivotal Trial Endpoints for Devices in Acute Decompensated Heart Failure

Clinically Meaningful and Practical Pivotal Trial Endpoints for Devices in Acute Decompensated Heart Failure

9 min.

Now is Not Soon Enough: Why Improving Patient Diversity in HF Trials is a Key Priority

Now is Not Soon Enough: Why Improving Patient Diversity in HF Trials is a Key Priority

10 min.

FDA Guidance on Meaningful Representation in Clinical Trials

FDA Guidance on Meaningful Representation in Clinical Trials

22 min.

Training Investigators to Advance Diversity and Inclusion

Training Investigators to Advance Diversity and Inclusion

9 min.

Recruitment Strategies for Vulnerable and Marginalized Trial Participants

Recruitment Strategies for Vulnerable and Marginalized Trial Participants

9 min.

The Leaders of the Pack: Why Improving Investigator Diversity in Heart Failure Trials is a Key Priority

The Leaders of the Pack: Why Improving Investigator Diversity in Heart Failure Trials is a Key Priority

17 min.

Regulatory Questions on Device Trials for Acute Decompensated Heart Failure - FDA Perspective

Regulatory Questions on Device Trials for Acute Decompensated Heart Failure - FDA Perspective

6 min.

Hot Topics on Regulatory Issues in Caridiogenic Shock - FDA Perspective

Hot Topics on Regulatory Issues in Caridiogenic Shock - FDA Perspective

8 min.

How Narrow or Broad Should Enrollment Criteria Be in Trials on Cardiogenic Shock  to Achieve Clinically Interpretable Results?

How Narrow or Broad Should Enrollment Criteria Be in Trials on Cardiogenic Shock to Achieve Clinically Interpretable Results?

7 min.

How Tightly Should Treatment Algorithms Be Prescribed in a Clinical Trial on Cardiogenic Shock? What Are The Key Treatment Protocol Elements?

How Tightly Should Treatment Algorithms Be Prescribed in a Clinical Trial on Cardiogenic Shock? What Are The Key Treatment Protocol Elements?

9 min.

Application of Exception from Informed Consent to a Multicenter Cardiogenic Shock Trial

Application of Exception from Informed Consent to a Multicenter Cardiogenic Shock Trial

9 min.

Debate: Revascularization in Chronic Heart Failure after REVIVED - Revascularize!

Debate: Revascularization in Chronic Heart Failure after REVIVED - Revascularize!

5 min.

Debate: Revascularization in Chronic Heart Failure after REVIVED - is GDMT enough?!

Debate: Revascularization in Chronic Heart Failure after REVIVED - is GDMT enough?!

4 min.

Latest Data From REVIVED

Latest Data From REVIVED

7 min.

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